Vac2 updates

Primary Outcome Measures : Treatment emergent adverse events [ Time Frame: Assessed from the time a patient consents to the main study until 30 days after a patient's last vaccination maximum of 6 weekly vaccines or until the patient starts another anti-cancer therapy, whichever is sooner.

Secondary Outcome Measures : Peripheral immune response [ Time Frame: Screening, vaccination weeks 3, 4 and 6, 2 weeks post last vaccination and 3, 6 and 12 months post a patient's first vaccination. Eligibility Criteria. Has had sufficient wash out periods from previous treatments as follows: i four weeks for chemotherapy ii six weeks for investigational medicinal products IMPs iii eight weeks for immunotherapy shorter intervals may be acceptable based on half-life of treatment.

Measurable disease Biopsiable disease is preferable however patients without biopsiable disease can still be considered for the study. Written signed and dated informed consent and be capable of co-operating with treatment and follow-up. Life expectancy of at least 12 weeks.

Exclusion Criteria: Radiotherapy except for palliative reasons during the previous four weeks before treatment. Exceptions to this are alopecia or certain Grade 2 toxicities, which in the opinion of the Investigator and the Sponsor should not exclude the patient.

Systemic steroids or other drugs with a likely effect on immune competence are forbidden during the trial. The predictable need of their use will preclude the patient from trial entry. Female patients who are able to become pregnant or are already pregnant or lactating. Men with partners of child-bearing potential must also be willing to ensure that their partner uses an effective method of contraception for the same duration for example, hormonal contraception, intrauterine device, diaphragm with spermicidal gel or sexual abstinence.

Men with pregnant or lactating partners must be advised to use barrier method contraception for example, condom plus spermicidal gel to prevent exposure of the foetus or neonate treatment arms only Major thoracic or abdominal surgery from which the patient has not yet recovered.

At high medical risk because of non-malignant systemic disease including active uncontrolled infection. Evidence of any ongoing active autoimmune disease. Any condition which might interfere with the patient's ability to generate an immune response. Abstinence is only considered to be an acceptable method of contraception when this is in line with the preferred and usual lifestyle of the subject.

Periodic abstinence e. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. Layout table for location contacts Contact: Christian Ottensmeier, Prof c.

More Information. Non-small cell lung cancer Immunotherapy Cancer vaccine Dendritic cell vaccine Allogeneic vaccine. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. When a cheat infraction is detected, the offender will be permanently banned from playing on secure servers. In lighter news, work is progressing on Lost Coast, that is the level we've built to showcase a new piece of rendering technology coming to Source called High Dynamic Range lighting, first mentioned here.

Stay tuned on SK-Gaming for further info. More from hancu- Rendezvous Under Way. View All Related News. HeatoN enters Esports Hall of Fame. SK's Impossible Dominance in Moments: ESWC President Kais Saied, who suspended parliament in July , announced new measures against mounting coronavirus cases on Wednesday, including a ban on public gatherings starting Thursday evening. The winners of the Asian Champions League are set to be decided in with a big split in match schedules for the east and west regions, the Asian Football Confederation said.

The two reasons cited for the new plan, which would see the league final played in February , were travel challenges during the COVID pandemic and the unusual scheduling of the World Cup in Qatar during November and December. Reported cases in the region rose 89 percent in the first week of January from a week earlier but deaths fell by 13 percent, WHO Regional Director Ahmed al-Mandhari said. Out of 22 mostly Middle Eastern countries in the region, 15 have officially reported cases of the highly infectious Omicron variant.

Al-Mandhari said six countries in the region — Afghanistan, Djibouti, Somalia, Sudan, Syria and Yemen — have vaccinated less than 10 percent of their populations despite having enough vaccines available to protect up to 40 percent. A South African pulmonologist said unvaccinated patients are still contracting severe COVID disease, despite evidence suggesting the Omicron coronavirus causes milder symptoms. Finland has cut the length of its COVID quarantine from 10 days to five for most cases, its public health authority said.

Finland reported 53, new COVID cases across a week, up by more than 27 percent from the week before, but authorities said the numbers were no longer reliable due to a lack of testing capacity. In the UK, fully vaccinated people no longer have to self-isolate after coming into contact with an infected person.

The emirate of Ajman has warned government employees that they will be penalised for coming into contact for a second time with anyone who has contracted COVID, UAE media have reported. Federal employees in Ajman will not receive paid sick leave for quarantine if they come into close contact with infected people outside the workplace or home for a second time.

The list includes failure to wear masks, being in crowded areas, shaking hands with others and going to the office after being in contact with someone who has contracted the coronavirus. Indian cities could see new COVID infections peak next week, experts said, as the country reported the highest number of daily cases since late May. Read more here. Some , Paxlovid pills, enough for 21, people, have arrived and will be distributed to pharmacies and 90 residential treatment centres, the Korea Disease Control and Prevention Agency KDCA said.

France has announced it was slightly easing COVID protocols for travellers from the UK, saying that the proof of an essential reason for the trip and a requirement to self-isolate upon arrival would no longer be required. AstraZeneca said data from a trial it conducted on its COVID vaccine, Vaxzevria, showed it generated a higher antibody response against Omicron and other strains when given as a third booster dose.

The increased response was seen in people who were previously vaccinated with either Vaxzevria or an mRNA vaccine, the drugmaker said, adding that it would submit this data to regulators worldwide given the urgent need for boosters. WHO spokesperson Tarik Jasarevic told Al Jazeera that attention on the spread of the new coronavirus variant must remain high, dismissing recent calls to debate the possibility of treating COVID as an endemic illness akin to the flu.

Jasarevic said more efforts must be made to reach the unvaccinated, especially in the 36 countries that have vaccinated less than 10 percent of their total population. France has approved new measures to tackle the coronavirus pandemic, including the requirement for residents to prove their vaccination status to access restaurants and bars, cultural venues, or interregional public transport.