National Center for Biotechnology Information , U. Ther Adv Infect Dis. Published online Jul Rachael Barr , Christopher A. Green , Charles J. Sande , and Simon B. Author information Article notes Copyright and License information Disclaimer.
Email: ten. Received Feb 11; Accepted Jul 3. This article has been cited by other articles in PMC. Abstract Respiratory syncytial virus RSV is responsible for a large burden of disease globally and can present as a variety of clinical syndromes in children of all ages.
Keywords: cohorting, infection control, nosocomial infection, palivizumab, respiratory syncytial virus, RSV.
Introduction Respiratory syncytial virus RSV is a ubiquitous pathogen infecting almost all children by 2 years of age. RSV bronchiolitis Bronchiolitis is an inflammatory process in the small airways of the lungs and is the most common clinical syndrome associated with RSV infection.
Clinical usefulness of respiratory virus testing Respiratory viral testing may be used in a clinical setting to increase confidence in the diagnosis of a viral, rather than bacterial, cause for respiratory illness. Investigations and treatment for RSV infection As discussed above, respiratory viral testing may be of some benefit in the investigation of children with symptoms suggestive of RSV infection.
Transmission of RSV and preventing nosocomial infections in hospital RSV is a human restricted pathogen and typically spreads via hands, fomites and the aerosol route. Preventing severe RSV infection A number of independent risk factors have been shown to be associated with RSV hospitalization as highlighted above.
Chronic respiratory morbidity after RSV infection in infancy Severe RSV bronchiolitis in the first year of life is associated with an increased risk of wheeze and asthma in later life. Future horizons in RSV vaccines and other anti-RSV therapeutics Given the huge burden of disease and the associated costs caused by RSV globally there is much ongoing research into the development of a well-tolerated and effective vaccine.
Summary RSV is a ubiquitous infection with a significant global clinical and financial burden. References 1. Defining the epidemiology and burden of severe respiratory syncytial virus infection among infants and children in western countries. Infect Dis Ther ; 5 : — Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in a systematic review and modelling study.
Lancet ; : — Pediatric investigators collaborative network on infections in canada study of respiratory syncytial virus—associated deaths in pediatric patients in Canada, — Clin Infect Dis ; 68 : — Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis.
Lancet London, England ; : — Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK. BMJ Open ; 6 : e Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma.
Arch Dis Child ; : — Burden of paediatric respiratory syncytial virus disease and potential effect of different immunisation strategies: a modelling and cost-effectiveness analysis for England. Lancet Public Heal ; 2 : e—e Risk factors for hospital admission with RSV bronchiolitis in England: a population-based birth cohort study.
Schildgen O, editor. PLoS One. Respiratory syncytial virus-associated hospitalizations among infants and young children in the United States, — Pediatr Infect Dis J ; 31 : 5—9. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics ; : e—e Viral pneumonia. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J ; 32 : — Clinical and epidemiologic factors related to subsequent wheezing after virus-induced lower respiratory tract infections in hospitalized pediatric patients younger than 3 years.
Eur J Pediatr ; : — Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol ; 42 : — Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol ; : — Role of viral respiratory infections in asthma and asthma exacerbations.
Impact of rapid molecular respiratory virus testing on real-time decision making in a pediatric emergency department. J Mol Diagn ; 19 : — How to use. Rapid tests for influenza, respiratory syncytial virus, and other respiratory viruses: a systematic review and meta-analysis. Clin Infect Dis ; 65 : — Arch Pediatr Adolesc Med ; : Impact of rapid influenza testing at triage on management of febrile infants and young children.
Pediatr Emerg Care ; 22 : — Impact of the rapid diagnosis of influenza on physician decision-making and patient management in the pediatric emergency department: results of a randomized, prospective, controlled trial. Pediatrics ; : — The rapid diagnosis of viral respiratory tract infections and its impact on antimicrobial stewardship programs. J Clin Virol ; : 84— Bronchodilators for bronchiolitis. In: Gadomski AM. Cochrane Database of Systematic Reviews. Glucocorticoids for acute viral bronchiolitis in infants and young children.
In: Fernandes RM. Antibiotics for bronchiolitis in children under two years of age. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This content does not have an English version. This content does not have an Arabic version. Diagnosis Your doctor may suspect respiratory syncytial virus based on the findings of a physical exam and the time of year the symptoms occur. More Information Chest X-rays.
Request an Appointment at Mayo Clinic. Share on: Facebook Twitter. Show references Kliegman RM, et al. Respiratory syncytial virus. In: Nelson Textbook of Pediatrics. Elsevier; Accessed Oct. Ferri FF. In: Ferri's Clinical Advisor Hurley LP, et al. Primary care physicians' perspectives on respiratory syncytial virus RSV disease in adults and a potential RSV vaccine for adults.
Chen X, et al. Applied Microbiology and Biotechnology. Respiratory syncytial virus infection RSV : Symptoms and care. Keywords: RSV; cohorting; infection control; nosocomial infection; palivizumab; respiratory syncytial virus. Abstract Respiratory syncytial virus RSV is responsible for a large burden of disease globally and can present as a variety of clinical syndromes in children of all ages. Publication types Review.
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